Structure of PDB 4zyc Chain B

Receptor sequence
>4zycB (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPELLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB4zyc Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4SS B K51 L54 F55 G58 F86 F91 V93 H96 K26 L29 F30 G33 F61 F66 V68 H71 MOAD: ic50=0.38uM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4zyc, PDBe:4zyc, PDBj:4zyc
PDBsum4zyc
PubMed26141769
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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