Structure of PDB 4zy6 Chain B

Receptor sequence
>4zy6B (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQ
QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD
VVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVK
LTDFGFSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEP
PYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSA
KELLQHQFLKIAKPLSSLTPLIAAAKEATK
3D structure
PDB4zy6 Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.
ChainB
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N389 K391 D393 N394 D407 T427
Catalytic site (residue number reindexed from 1) N135 K137 D139 N140 D153 T165
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4T6 B I276 V284 A297 E345 Y346 L347 G350 D393 N394 L396 T406 I22 V30 A43 E91 Y92 L93 G96 D139 N140 L142 T152 MOAD: Ki=5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4zy6, PDBe:4zy6, PDBj:4zy6
PDBsum4zy6
PubMed26030457
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

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