Structure of PDB 4zy4 Chain B

Receptor sequence
>4zy4B (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAI
KQMNLQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG
GSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGM
DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWS
LGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLN
RCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT
3D structure
PDB4zy4 Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N389 K391 D393 N394 D407 P416 T427
Catalytic site (residue number reindexed from 1) N140 K142 D144 N145 D158 P167 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4T3 B A297 Y346 L347 A348 G350 D393 L396 T406 D407 A49 Y97 L98 A99 G101 D144 L147 T157 D158 BindingDB: Ki=22nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4zy4, PDBe:4zy4, PDBj:4zy4
PDBsum4zy4
PubMed26030457
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

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