Structure of PDB 4zwe Chain B

Receptor sequence

>4zweB (length=480) Species: 9606 (Homo sapiens) [Search protein sequence]

TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD
CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL
HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY
TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK
REDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS
FYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYF
VQWCADRNFTKPQDGDVIAPLIVPQKKEWN

3D structure

PDB

4zwe Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592.

Chain

Resolution

2.81 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	B	V117 N119	V4 N6
BS02	DGT	B	Q149 R164 H215 H233 D311 Y315 H370 Y374 Q375	Q36 R51 H102 H120 D192 Y196 H251 Y255 Q256
BS03	MG	B	R206 K312	R93 K193
BS04	DGT	B	K116 V117 I118 D137 R145	K3 V4 I5 D24 R32
BS05	DGT	B	R333 R352 K354 K523	R214 R233 K235 K404
BS06	DGT	B	Y155 V156 V378 R451	Y42 V43 V259 R332
BS07	DGT	B	V156 F157 R372 H376 K377	V43 F44 R253 H257 K258

External links

PDB	RCSB:4zwe, PDBe:4zwe, PDBj:4zwe
PDBsum	4zwe
PubMed	26294762
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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