Structure of PDB 4zt3 Chain B

Receptor sequence
>4zt3B (length=526) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
GPGSMKVEKVFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVF
ALTGTDEHGQKVAEAAKQKQVSPYDFTTAVAGEFKKCFEQMDYSIDYFIR
TTNEQHKAVVKELWTKLEQKGDIYLGRYEGWYSISDESFLTPQNITKVSL
ESGHVVTWVSEENYMFRLSAFRERLLEWYHANPGCIVPEFRRREVIRAVE
KGLPDLSVSRARATLHNWAIPVPGNPDHCVYVWLDALTNYLTGSRLRVDE
SGKEVSLVDDFNELERFPADVHVIGKDILKFHAIYWPAFLLSAGLPLPKK
IVAHGWWTKDRKKISKSLGNVFDPVEKAEEFGYDALKYFLLRESGFSDDG
DYSDKNMIARLNGELADTLGNLVMRCTSAKINVNGEWPSPAAYTEEDESL
IQLIKDLPGTADHYYLIPDIQKAIIAVFDVLRAINAYVTDMAPWKLVKTD
PERLRTVLYITLEGVRVTTLLLSPILPRKSVVIFDMLGVPEVHRKGIENF
EFGAVPPGTRLGPAVEGEVLFSKRST
3D structure
PDB4zt3 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H256 H259 S364 D367 S390 S393 K554 K557
Catalytic site (residue number reindexed from 1) H25 H28 S133 D136 S149 S152 K313 K316
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4RQ B I248 Y250 D287 G290 Y472 V473 I519 F522 H523 I17 Y19 D56 G59 Y231 V232 I278 F281 H282
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4zt3, PDBe:4zt3, PDBj:4zt3
PDBsum4zt3
PubMed27627628
UniProtQ38C91

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