Structure of PDB 4zsy Chain B

Receptor sequence
>4zsyB (length=460) Species: 9823 (Sus scrofa) [Search protein sequence]
DYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVD
GNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF
VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGESAF
SKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIP
SFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAG
IIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFW
AHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKN
LLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTF
CSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFL
NIFSDILADF
3D structure
PDB4zsy Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F189 E265 D298 Q301 K329 T353 R445
Catalytic site (residue number reindexed from 1) F178 E254 D287 Q290 K318 T342 R434
Enzyme Commision number 2.6.1.19: 4-aminobutyrate--2-oxoglutarate transaminase.
2.6.1.22: (S)-3-amino-2-methylpropionate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FES B C135 C138 C124 C127
BS02 RW2 B F351 T353 F340 T342
BS03 RW2 B I72 C135 G136 S137 F189 H190 R192 D298 V300 Q301 K329 I61 C124 G125 S126 F178 H179 R181 D287 V289 Q290 K318
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0032145 succinate-semialdehyde dehydrogenase binding
GO:0034386 4-aminobutyrate:2-oxoglutarate transaminase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0009448 gamma-aminobutyric acid metabolic process
GO:0009450 gamma-aminobutyric acid catabolic process
GO:0048148 behavioral response to cocaine
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0032144 4-aminobutyrate transaminase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zsy, PDBe:4zsy, PDBj:4zsy
PDBsum4zsy
PubMed26110556
UniProtP80147|GABT_PIG 4-aminobutyrate aminotransferase, mitochondrial (Gene Name=ABAT)

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