Structure of PDB 4zrp Chain B

Receptor sequence
>4zrpB (length=399) Species: 9606 (Homo sapiens) [Search protein sequence]
EMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTK
EDLYLHSLKLGYQQCLLCQGKPSMGQLALYLLALRANCEFVRGHKGDRLV
SQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDK
LLYAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVQE
EILKAQTPEGHFGNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASL
QDGAFQNALMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAETIPQTQE
IISVTLQVLSLLPPYRQSISVLAGSTVEDVLKKAHELGGFTYETQASLSG
PYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW
3D structure
PDB4zrp Structural basis of transcobalamin recognition by human CD320 receptor.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CNC B G85 Q86 Y137 Q138 D176 N224 Y226 M270 S357 L358 S359 G360 P361 Y362 L363 F376 W377 Q378 L379 L387 L388 G390 W409 G75 Q76 Y127 Q128 D166 N214 Y216 M260 S347 L348 S349 G350 P351 Y352 L353 F366 W367 Q368 L369 L377 L378 G380 W399
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
GO:0140355 cargo receptor ligand activity
Biological Process
GO:0006824 cobalt ion transport
GO:0015889 cobalamin transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0043202 lysosomal lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zrp, PDBe:4zrp, PDBj:4zrp
PDBsum4zrp
PubMed27411955
UniProtP20062|TCO2_HUMAN Transcobalamin-2 (Gene Name=TCN2)

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