Structure of PDB 4zri Chain B

Receptor sequence
>4zriB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
TFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKD
TVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLP
KRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVN
YFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE
FTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRR
3D structure
PDB4zri Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E136 V139 L176 Y177 M179 R187 W191 E206 K209 I210 E116 V119 L156 Y157 M159 R167 W171 E186 K189 I190
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

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Molecular Function
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Cellular Component
External links
PDB RCSB:4zri, PDBe:4zri, PDBj:4zri
PDBsum4zri
PubMed26045165
UniProtP35240|MERL_HUMAN Merlin (Gene Name=NF2)

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