Structure of PDB 4zr1 Chain B

Receptor sequence
>4zr1B (length=275) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
FDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKD
FYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVA
LKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFL
LHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGL
FGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDE
VFGTYLGPDAPLSKMKYESGLEVLF
3D structure
PDB4zr1 The Crystal Structure of an Integral Membrane Fatty Acid alpha-Hydroxylase.
ChainB
Resolution2.6008 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase.
1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H271 H326 H330 H345 H349 H155 H210 H214 H229 H233
BS02 ZN B H244 H249 H268 H272 H348 H128 H133 H152 H156 H232
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0080132 fatty acid 2-hydroxylase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008610 lipid biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4zr1, PDBe:4zr1, PDBj:4zr1
PDBsum4zr1
PubMed26515067
UniProtQ03529|SCS7_YEAST Ceramide very long chain fatty acid hydroxylase SCS7 (Gene Name=SCS7)

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