Structure of PDB 4zql Chain B

Receptor sequence
>4zqlB (length=176) Species: 9606 (Homo sapiens) [Search protein sequence]
MNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDL
SKPEVEYDCDAKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPL
TVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFN
EPDSEVANAGIKLENYFEELLKNLYP
3D structure
PDB4zql Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide inhibitor
ChainB
Resolution1.79 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C829 C832 H849 C852 C6 C9 H26 C29
BS02 ZN B C841 C844 C867 C870 C18 C21 C44 C47
BS03 4QH B A923 F924 V928 F979 N980 A93 F94 V98 F149 N150 BindingDB: IC50=750nM,Kd=222nM
External links
PDB RCSB:4zql, PDBe:4zql, PDBj:4zql
PDBsum4zql
PubMed
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

[Back to BioLiP]