Structure of PDB 4zpk Chain B

Receptor sequence
>4zpkB (length=321) Species: 10090 (Mus musculus) [Search protein sequence]
KRSSSELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIM
RLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGD
MIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLSTERDFFM
RMKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNLSCLIIMCEPIQHPSHM
DIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPEELLGRSAYEFYHALD
SENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNLQPQCIM
CVNYVLSEIKNDVVFSMDQTE
3D structure
PDB4zpk Structural integration in hypoxia-inducible factors.
ChainB
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K18 R26 N184 K186 K11 R19 N164 K166 PDBbind-CN: Kd=45nM
BS02 dna B K16 S19 R20 R24 R27 K53 K9 S12 R13 R17 R20 K46 PDBbind-CN: Kd=45nM
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zpk, PDBe:4zpk, PDBj:4zpk
PDBsum4zpk
PubMed26245371
UniProtP97481|EPAS1_MOUSE Endothelial PAS domain-containing protein 1 (Gene Name=Epas1)

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