Structure of PDB 4znt Chain B

Receptor sequence

>4zntB (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQL
LLILSHIRHMSNKGMEHLYSLSDLLLEMLDAHR

3D structure

PDB

4znt Predictive features of ligand-specific signaling through the estrogen receptor.

Chain

Resolution

1.903 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 K362 L372 V376 E380 D538 E542 M543	I54 K58 L68 V72 E76 D223 E227 M228
BS02	OBB	B	M343 L346 T347 E353 L387 M388 L391 F404 E419 M421 I424 G521 H524 L525	M39 L42 T43 E49 L83 M84 L87 F100 E115 M117 I120 G214 H217 L218

External links

PDB	RCSB:4znt, PDBe:4znt, PDBj:4znt
PDBsum	4znt
PubMed	27107013
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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