Structure of PDB 4zn9 Chain B

Receptor sequence

>4zn9B (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTS

3D structure

PDB

4zn9 Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands.

Chain

Resolution

2.215 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 K362 L372 V376 E380 D538 E542	I54 K58 L68 V72 E76 D219 E223
BS02	OBH	B	A350 E353 L387 L391 F404 M421 I424 H524 L525	A46 E49 L83 L87 F100 M117 I120 H205 L206

External links

PDB	RCSB:4zn9, PDBe:4zn9, PDBj:4zn9
PDBsum	4zn9
PubMed	22517684
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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