Structure of PDB 4zn7 Chain B

Receptor sequence

>4zn7B (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR

3D structure

PDB

4zn7 Predictive features of ligand-specific signaling through the estrogen receptor.

Chain

Resolution

1.934 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 K362 L372 Q375 V376 E380 D538 L539 E542	I54 K58 L68 Q71 V72 E76 D226 L227 E230
BS02	DES	B	M343 A350 E353 L387 F404 M421 H524 L525	M39 A46 E49 L83 F100 M117 H212 L213	BindingDB: Ki=0.128000nM,IC50=0.330000nM,EC50=0.110000nM

External links

PDB	RCSB:4zn7, PDBe:4zn7, PDBj:4zn7
PDBsum	4zn7
PubMed	27107013
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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