Structure of PDB 4zkl Chain B

Receptor sequence
>4zklB (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
PGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQ
ISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVH
LHVLGGRQMHWPPG
3D structure
PDB4zkl Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
ChainB
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.-
3.9.1.-
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 AMP B D43 I44 N99 G105 Q106 S107 H112 H114 D31 I32 N87 G93 Q94 S95 H100 H102
BS02 JB6 B I22 D43 I44 S45 S107 V108 I10 D31 I32 S33 S95 V96
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0016929 deSUMOylase activity
GO:0043530 adenosine 5'-monophosphoramidase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0009154 purine ribonucleotide catabolic process
GO:0016926 protein desumoylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0070062 extracellular exosome

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:4zkl, PDBe:4zkl, PDBj:4zkl
PDBsum4zkl
PubMed26905466
UniProtP49773|HINT1_HUMAN Adenosine 5'-monophosphoramidase HINT1 (Gene Name=HINT1)

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