Structure of PDB 4zjr Chain B

Receptor sequence
>4zjrB (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQHVERLQ
3D structure
PDB4zjr Discovery of biaryl carboxylamides as potent ROR gamma inverse agonists.
ChainB
Resolution2.702 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4P3 B W317 C320 H323 M365 V376 F378 E379 F388 I397 H479 W53 C56 H59 M101 V112 F114 E115 F124 I133 H215 BindingDB: EC50=93nM,IC50=11nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zjr, PDBe:4zjr, PDBj:4zjr
PDBsum4zjr
PubMed26048806
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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