Structure of PDB 4zdo Chain B

Receptor sequence
>4zdoB (length=458) Species: 9606 (Homo sapiens) [Search protein sequence]
NRESFAAGERLYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFL
HELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQ
PKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTL
RHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAV
EAKVQELGPDCILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAY
GVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQE
ISKMYPGRASASPSLDVLISLLSLGSNGYKKLLKERKEMFSYLSNQIKKL
SEAYNERLLHTPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARV
VPLGSMQTVSGYTFRGFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLD
RCLKAVRK
3D structure
PDB4zdo Structural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase.
ChainB
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R75 R97 S98 Q105 Q172 A254 K284 R313
Catalytic site (residue number reindexed from 1) R70 R92 S93 Q100 Q167 A249 K279 R308
Enzyme Commision number 2.9.1.2: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B S393 M394 T397 R398 Q399 S388 M389 T392 R393 Q394
BS02 PLR B A143 T144 G145 Q172 S174 A254 Y255 K284 A138 T139 G140 Q167 S169 A249 Y250 K279
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0098621 O-phosphoseryl-tRNA(Sec) selenium transferase activity
Biological Process
GO:0001514 selenocysteine incorporation
GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zdo, PDBe:4zdo, PDBj:4zdo
PDBsum4zdo
PubMed27576344
UniProtQ9HD40|SPCS_HUMAN O-phosphoseryl-tRNA(Sec) selenium transferase (Gene Name=SEPSECS)

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