Structure of PDB 4z9m Chain B

Receptor sequence
>4z9mB (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
REQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCI
QTGVDNPIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHTTDL
DASKQQFSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLA
GRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHN
YDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWE
FMWNERLGYILTCPSNLGTGLRAGVHSNIDRIGRSEVELVQIVIDGVNYL
3D structure
PDB4z9m Crystal structure of human sarcomeric mitochondrial creatine kinase
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R166 E266 R270 C317 S319 R326
Catalytic site (residue number reindexed from 1) R112 E212 R216 C263 S265 R272
Enzyme Commision number 2.7.3.2: creatine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B S162 R164 R166 H225 M274 R326 H330 S108 R110 R112 H171 M220 R272 H276
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004111 creatine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006936 muscle contraction
GO:0016310 phosphorylation
GO:0046314 phosphocreatine biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z9m, PDBe:4z9m, PDBj:4z9m
PDBsum4z9m
PubMed
UniProtP17540|KCRS_HUMAN Creatine kinase S-type, mitochondrial (Gene Name=CKMT2)

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