Structure of PDB 4z7h Chain B

Receptor sequence
>4z7hB (length=388) Species: 9606 (Homo sapiens) [Search protein sequence]
SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADR
EVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL
GLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISD
FGLCKKLAVGRHVPGTEGWIAPEMLSPTYTVDIFSAGCVFYYVISEGSHP
FGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAK
HVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDW
RENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGS
LPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYF
3D structure
PDB4z7h Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.
ChainB
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D688 K690 N693 D711 T734
Catalytic site (residue number reindexed from 1) D127 K129 N132 D150 T166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4L5 B L577 G578 K599 C645 L695 D711 L16 G17 K38 C84 L134 D150 BindingDB: EC50=143nM,IC50=1180nM
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0030968 endoplasmic reticulum unfolded protein response

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4z7h, PDBe:4z7h, PDBj:4z7h
PDBsum4z7h
PubMed25968568
UniProtO75460|ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (Gene Name=ERN1)

[Back to BioLiP]