Structure of PDB 4z31 Chain B

Receptor sequence
>4z31B (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
NLGENKHYEVAKKCVEDLALYLKALSRPMQRKLVTLVNCQLVEEEGRVRA
MRAARSLGERTVTELILQHQNPQQLSANLWAAVRARGCQFLGPAMQEEAL
KLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASC
FKVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISPEQWS
SLLYGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLR
PHLELLANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYS
3D structure
PDB4z31 New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B S312 Q315 S316 D319 S211 Q214 S215 D218 PDBbind-CN: Kd=356nM
BS02 rna B K133 R153 S157 R161 K32 R52 S56 R60 PDBbind-CN: Kd=356nM
BS03 rna B R185 R216 S235 T237 Q244 Y247 R248 D260 S261 S262 R84 R115 S134 T136 Q143 Y146 R147 D159 S160 S161 PDBbind-CN: Kd=356nM
External links
PDB RCSB:4z31, PDBe:4z31, PDBj:4z31
PDBsum4z31
PubMed26489670
UniProtQ9HBD1|RC3H2_HUMAN Roquin-2 (Gene Name=RC3H2)

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