Structure of PDB 4z1x Chain B

Receptor sequence

>4z1xB (length=291) Species: 229533 (Fusarium graminearum PH-1)

SINPWFVTGFTDAEGSFMIHLEKNKDKWRVRPTFQIKLDIRDKSLLEEIK
NYFNNTGSINTSNKECVYKVRSLKDISIIISHFDKYNLITQKKADFELFK
KIINKLNSQEHLSYEVGATVLQEIISIRASMNLGLSSSVKEDFPHIIPSN
RPLIENMNIPHPEWMAGFVSGEGSFSVYTTSDDKYVSLSFRVSQHNKDKQ
LLKSFVDFFGCGGFNYHNKGNKAVIFVTRKFEDINDKIIPLFNEYKIKGV
KYKDFKDWSKVAKMIESKSHLTTNGYKEICKIKENMNSYRK

3D structure

• PDB: 4z1x Crystal structure of LAGLIDADG homing endonuclease I-GzeII in complex with DNA target
• Chain: B
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K32 R34 R36 N65 R76 L117 S118 E177 Y183 S186 R196 S198 Q199 H200 H222 N292 S293	K27 R29 R31 N60 R71 L112 S113 E172 Y178 S181 R191 S193 Q194 H195 H217 N287 S288
BS02	dna	B	A18 E19 S21 M23 H25 E27 Q40 K42 D44 R133 N137 L138 Y190 H222 K224 R234 K235 F236 H275	A13 E14 S16 M18 H20 E22 Q35 K37 D39 R128 N132 L133 Y185 H217 K219 R229 K230 F231 H270
BS03	CA	B	A18 E177	A13 E172
BS04	CA	B	E19 G176	E14 G171

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity

External links

• PDB: RCSB:4z1x, PDBe:4z1x, PDBj:4z1x
• PDBsum: 4z1x
• UniProt: A5J036