Structure of PDB 4z1s Chain B

Receptor sequence
>4z1sB (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
GSTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAV
KLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYN
KPGDDIVLMAEALEKLFLQKINELP
3D structure
PDB4z1s Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains.
ChainB
Resolution1.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 559 B W81 P82 L92 I146 W41 P42 L52 I106 MOAD: ic50=0.79uM
External links
PDB RCSB:4z1s, PDBe:4z1s, PDBj:4z1s
PDBsum4z1s
PubMed26985289
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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