Structure of PDB 4z1q Chain B

Receptor sequence
>4z1qB (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
GSTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAV
KLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYN
KPGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB4z1q Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains.
ChainB
Resolution1.399 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 558 B W81 P82 F83 L92 Y139 N140 I146 W41 P42 F43 L52 Y99 N100 I106 MOAD: ic50=0.015uM
External links
PDB RCSB:4z1q, PDBe:4z1q, PDBj:4z1q
PDBsum4z1q
PubMed26985289
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]