Structure of PDB 4z1d Chain B

Receptor sequence
>4z1dB (length=256) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
KSVLIAGPCVIESLENLRSIATKLQPLANNERLDFYFKASFDKANRTSLE
SYRGPGLEKGLEMLQTIKEEFGYKILTDVHESYQASVAAKVADILQIPAF
LCRQTDLIVEVSQTNAIVNIKKGQFMNPKDMQYSVLKALKTRDKSIQSPT
YETALKNGVWLCERGSSFGYGNLVVDMRSLKIMREFAPVIFDATHSVQMP
SFAPILARAAAAVGIDGLFAETHVDPKNALSDGANMLKPDELEQLVTDML
KIQNLF
3D structure
PDB4z1d Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
ChainB
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.55: 3-deoxy-8-phosphooctulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PEP B K47 K52 Q105 P107 A108 K130 R173 H204 K38 K43 Q96 P98 A99 K121 R164 H195
BS02 ZN B C18 H204 E241 C9 H195 E221
Gene Ontology
Molecular Function
GO:0008676 3-deoxy-8-phosphooctulonate synthase activity
GO:0016740 transferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0019294 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4z1d, PDBe:4z1d, PDBj:4z1d
PDBsum4z1d
PubMed26649906
UniProtP56060|KDSA_HELPY 2-dehydro-3-deoxyphosphooctonate aldolase (Gene Name=kdsA)

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