Structure of PDB 4yzw Chain B

Receptor sequence
>4yzwB (length=682) Species: 7165 (Anopheles gambiae) [Search protein sequence]
TLTQKFHGLLQHPLEPLFLPKNDGTLFYDLPERFLTSRYSPIGQNLANRF
GPNSPASSQVSNPPTVVTIKDLDELPDLTFATWIKRRDSFSLFNPEHRKA
AGKLTKLFLDQPNADRLVDVAAYARDRLNAPLFQYALSVALLHRPDTKSV
SVPSLLHLFPDQFIDPAAQVRMMEEGSIVLDENRMPIPIPMNYTATDAEP
EQRMAFFREDIGVNLHHWHWHLVYPASGPPDVVRKDRRGELFYYMHQQLL
ARYQIDRYAQGLGRIEPLANLREPVREAYYPKLLRTSNNRTFCPRYPGMT
ISDVARSADRLEVRIADIESWLPRVLEAIDAGFAVSDDGVRVPLDETRGI
DVLGNILERSAISINRNLYGDVHNMGHVLLAFIHDPRGTYLESSGVMGGV
ATAMRDPIFYRWHKFIDNIFLRNKARLAPYTMAELSNSNVTLEALETQLD
RAGGAVNSFVTFWQRSQVDLRAGIDFSAAGSAFVSFTHLQCAPFVYRLRI
NSTARSNRQDTVRIFLLPRQNEQGRPLSFEDRRLLAIELDSFRVNLRPGM
NNIVRQSSNSSVTIPFERTFGNQSRFCGCGWPAHMLLPKGNANGVEFDLF
AMVSRFEDDNANVNYDENAGCDDSYAFCGLRDRVYPSRRAMGFPFDRRAS
NGVRSVADFVAPYKNMRLATVTLRFMNTIIDR
3D structure
PDB4yzw The structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.10.3.-
1.14.18.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU B H223 H227 H252 H217 H221 H246
BS02 CU B H379 H383 H419 H373 H377 H413
Gene Ontology
Molecular Function
GO:0004097 catechol oxidase activity
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4yzw, PDBe:4yzw, PDBj:4yzw
PDBsum4yzw
PubMed26732497
UniProtQ8MZM3|PPO8_ANOGA Phenoloxidase 8 (Gene Name=PPO8)

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