Structure of PDB 4yzm Chain B

Receptor sequence
>4yzmB (length=262) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
RLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGETEMIE
KFQEFQREVFIMSNLNHPNIVKLYGLMHNPPRMVMELVPCGDLYHRLLDK
AHPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNILLQSLDENAP
VCAKVADFGLSQLLGNFQWMAPETIGAESYTEKADTYSFAMILYTILTGE
GPFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRP
HFSYIVKELSEL
3D structure
PDB4yzm Structural Characterization of LRRK2 Inhibitors.
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1154 R1156 P1158 N1159 D1177 N1194
Catalytic site (residue number reindexed from 1) D134 R136 P138 N139 D157 N166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4K4 B V1040 K1055 E1106 L1107 V1108 P1109 G1111 L1161 V24 K39 E86 L87 V88 P89 G91 L141
BS02 MG B D1154 D1177 D134 D157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4yzm, PDBe:4yzm, PDBj:4yzm
PDBsum4yzm
PubMed25897865
UniProtQ6XHB2|ROCO4_DICDI Probable serine/threonine-protein kinase roco4 (Gene Name=roco4)

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