Structure of PDB 4yv2 Chain B

Receptor sequence
>4yv2B (length=273) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
GWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMAL
DGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHG
TVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPD
NTYDVVIIDTEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRE
TGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDL
KYYDSEMHKASFALPRFARHINN
3D structure
PDB4yv2 Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase
ChainB
Resolution2.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M B Q40 L59 Q64 H74 G95 D98 D118 I119 G150 D168 T169 Q31 L50 Q55 H65 G86 D89 D109 I110 G141 D159 T160
BS02 4K3 B M24 S25 L26 W53 I63 M15 S16 L17 W44 I54 PDBbind-CN: -logKd/Ki=7.29,IC50=0.051uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4yv2, PDBe:4yv2, PDBj:4yv2
PDBsum4yv2
PubMed26327378
UniProtQ4DA73

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