Structure of PDB 4yv1 Chain B

Receptor sequence
>4yv1B (length=288) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWG
TVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLRE
VLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFV
RQTPDNTYDVVIIDTTDPAGPASKLFAFYKDVLRILKPDGICCNQGESIW
LDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVT
KPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN
3D structure
PDB4yv1 Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase
ChainB
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M B Q40 L59 Q64 H74 G95 D98 D118 I119 D149 G150 D168 T169 T170 P175 A176 L179 Q36 L55 Q60 H70 G91 D94 D114 I115 D145 G146 D164 T165 T166 P171 A172 L175
BS02 4K2 B E14 W19 Q22 M24 P238 C239 E10 W15 Q18 M20 P232 C233 MOAD: ic50=830uM
PDBbind-CN: -logKd/Ki=3.08,IC50=830uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4yv1, PDBe:4yv1, PDBj:4yv1
PDBsum4yv1
PubMed26327378
UniProtQ4DA73

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