Structure of PDB 4ypu Chain B

Receptor sequence
>4ypuB (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
GSYKKIRSNVYVDVKPLSGYCVDDCLNRMIFAECSPNTCPCGEQCCNQRI
QRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRM
IEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNG
VYRIGLYALKDMPAGTELTYDYNFHQQLCKCGFEKCRGII
3D structure
PDB4ypu Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y2169 Y2255
Catalytic site (residue number reindexed from 1) Y86 Y172
Enzyme Commision number 2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C2220 C2270 C2275 C137 C181 C186
BS02 ZN B C2104 C2117 C2122 C2128 C21 C34 C39 C45
BS03 ZN B C2104 L2109 C21 L26
BS04 SAM B K2150 G2151 W2152 D2192 H2193 Y2194 F2215 N2217 H2218 Y2255 Q2266 K2269 K67 G68 W69 D109 H110 Y111 F132 N134 H135 Y172 Q177 K180
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:4ypu, PDBe:4ypu, PDBj:4ypu
PDBsum4ypu
PubMed26292256
UniProtQ9NR48|ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (Gene Name=ASH1L)

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