Structure of PDB 4ype Chain B

Receptor sequence
>4ypeB (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
GSYKKIRSNVYVDVKPLSGYEATTCCVDDCLNRMIFAECSPNTCPCGEQC
CNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQE
FRNRMIEQYHNHSDFYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQK
WSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGI
IG
3D structure
PDB4ype Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y2169 Y2255
Catalytic site (residue number reindexed from 1) Y91 Y177
Enzyme Commision number 2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C2220 C2268 C2270 C2275 C142 C190 C192 C197
BS02 ZN B C2104 C2117 C2128 C26 C39 C50
BS03 ZN B C2091 C2104 C2108 C25 C26 C30
BS04 SAM B K2150 W2152 D2192 F2193 Y2194 R2214 F2215 N2217 H2218 Y2255 K2269 I2279 K72 W74 D114 F115 Y116 R136 F137 N139 H140 Y177 K191 I201
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:4ype, PDBe:4ype, PDBj:4ype
PDBsum4ype
PubMed26292256
UniProtQ9NR48|ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (Gene Name=ASH1L)

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