Structure of PDB 4yp5 Chain B

Receptor sequence
>4yp5B (length=169) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H) [Search protein sequence]
TMRGLLVGRMQPFHRGHLQVIKSILEEVDELIICIGSAQLSHSIRDPFTA
GERVMMLTKALSENGIPASRYYIIPVQDIECNALWVGHIKMLTPPFDRVY
SGNPLVQRLFSEDGYEVTAPPLFYRDRYSGTEVRRRMLDDGDWRSLLPES
VVEVIDEINGVERIKHLAK
3D structure
PDB4yp5 Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotides.
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.1: nicotinamide-nucleotide adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B V9 R11 H16 H19 G38 S39 D80 I81 N84 W87 N105 Y126 S131 G132 V7 R9 H14 H17 G36 S37 D78 I79 N82 W85 N103 Y124 S129 G130 MOAD: Ki=65uM
Gene Ontology
Molecular Function
GO:0000309 nicotinamide-nucleotide adenylyltransferase activity
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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External links
PDB RCSB:4yp5, PDBe:4yp5, PDBj:4yp5
PDBsum4yp5
PubMed26457427
UniProtO26253|NADM_METTH Nicotinamide-nucleotide adenylyltransferase (Gene Name=MTH_150)

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