Structure of PDB 4ynm Chain B

Receptor sequence
>4ynmB (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
GSYKKIRSNVYVDVKPLSGYCVDDCLNRMIFAECSPNTCPCGEQCCNQRI
QRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRM
IEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNG
VYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGII
3D structure
PDB4ynm Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
ChainB
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y2169 Y2255
Catalytic site (residue number reindexed from 1) Y86 Y172
Enzyme Commision number 2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C2220 C2268 C2270 C2275 C137 C185 C187 C192
BS02 ZN B C2104 C2117 C2122 C2128 C21 C34 C39 C45
BS03 SAM B W2152 D2192 H2193 Y2194 R2214 F2215 N2217 H2218 Y2255 Q2266 C2268 K2269 I2279 W69 D109 H110 Y111 R131 F132 N134 H135 Y172 Q183 C185 K186 I196
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:4ynm, PDBe:4ynm, PDBj:4ynm
PDBsum4ynm
PubMed26292256
UniProtQ9NR48|ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (Gene Name=ASH1L)

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