Structure of PDB 4yke Chain B

Receptor sequence
>4ykeB (length=405) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
TAGPDTIRILVSTDNHVGYEERDPIRKDDSWRTFDEIMQLARTKDVDMVL
LGGDLFHDNKPSRKAMYQVMRSLRKNCLGMKPCELEFLSDPAEVFEGAFP
HVNYYDPDINVSIPVFSIHGNHDDPSGDGHLCSLDLLQVAGLVNYFGRVP
EADNIHVKPILLQKGKTKLALYGMSNVRDERIHRTFRDNKVRFYRPSQQT
GDWFNLLTLHQNHYAHTPTGYLSENMLPDFLDLVIWGHEHECLIDPKKNP
ETGFHVMQPGSSIATSLVPGEAVPKHIAILSITGKSFEVEKIPLRTVRPF
VIREITLATDKRFKGLEKKQDNRQEVTKRLMQIVEEMIAEANEMWRSLHE
DSQDDQPLPLIRLKVEYSSPEGTKFEVENPQRFSNRFAGKVANQNDVVHF
YRKKT
3D structure
PDB4yke Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.
ChainB
Resolution2.783 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D17 H19 D57 H243 D14 H16 D54 H240
BS02 MN B D57 N124 H213 H241 D54 N121 H210 H238
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
Biological Process
GO:0006302 double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0030870 Mre11 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4yke, PDBe:4yke, PDBj:4yke
PDBsum4yke
PubMed26057807
UniProtG0RYR3|MRE11_CHATD Double-strand break repair protein MRE11 (Gene Name=MRE11)

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