Structure of PDB 4ydg Chain B

Receptor sequence

>4ydgB (length=111) Species: 11926 (Human T-cell lymphotrophic virus type 1 (strain ATK))

PVIPLDPARRPVIKAQVDTQTSHPKTIEALLDTGADMTVIPIALFSSNTP
LKNTSVLTQDHFKLTSLPVLIRLPFRTTPIVLTSCLVDTKNNWAIIGRDA
LQQCQGVLYLP

3D structure

• PDB: 4ydg Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C2-Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors.
• Chain: B
• Resolution: 3.25 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	G3G	B	D32 G34 A35 D36 M37 W98	D32 G34 A35 D36 M37 W93	PDBbind-CN: -logKd/Ki=7.82,Ki=0.015uM

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:4ydg, PDBe:4ydg, PDBj:4ydg
• PDBsum: 4ydg
• PubMed: 26000468
• UniProt: P03362|POL_HTL1A Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)