Structure of PDB 4ybo Chain B

Receptor sequence

>4yboB (length=381) Species: 273075 (Thermoplasma acidophilum DSM 1728)

EEISKGLEDVNIKWTRLTTIDGNKGILRYGGYSVEDIIASGAQDEEIQYL
FLYGNLPTEQELRKYKETVQKGYKIPDFVINAIRQLPRESDAVAMQMAAV
AAMAASETKFKWNKDTDRDVAAEMIGRMSAITVNVYRHIMNMPAELPKPS
DSYAESFLNAAFGRKATKEEIDAMNTALILYTDHEVPASTTAGLVAVSTL
SDMYSGITAALAALKGPLHGGAAEAAIAQFDEIKDPAMVEKWFNDNIING
KKRLMGFGHRVYKTYDPRAKIFKGIAEKLSSKKPEVHKVYEIATKLEDFG
IKAFGSKGIYPNTDYFSGIVYMSIGFPLRNNIYTALFALSRVTGWQAHFI
EYVEEQQRLIRPRAVYVGPAERKYVPIAERK

3D structure

• PDB: 4ybo An active site-tail interaction in the structure of hexahistidine-tagged Thermoplasma acidophilum citrate synthase.
• Chain: B
• Resolution: 2.179 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S192 H222 H262 R271 D317
• Catalytic site (residue number reindexed from 1): S189 H219 H259 R268 D314
• Enzyme Commision number: 2.3.3.16: citrate synthase (unknown stereospecificity).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BCT	B	K286 E288 V289	K283 E285 V286

Gene Ontology

Molecular Function

• GO:0004108 citrate (Si)-synthase activity
• GO:0016740 transferase activity
• GO:0036440 citrate synthase activity
• GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006099 tricarboxylic acid cycle

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4ybo, PDBe:4ybo, PDBj:4ybo
• PDBsum: 4ybo
• PubMed: 26457521
• UniProt: P21553|CISY_THEAC Citrate synthase (Gene Name=gltA)