Structure of PDB 4ybm Chain B

Receptor sequence
>4ybmB (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLS
KPEVEYDCDAPVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYY
KIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEV
ANAGIKLENYFEELLKNLYP
3D structure
PDB4ybm Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
ChainB
Resolution1.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4BJ B Y936 T947 R951 M958 Y100 T111 R115 M122 MOAD: ic50=0.14uM
PDBbind-CN: -logKd/Ki=6.85,IC50=0.14uM
BindingDB: EC50=3900nM,IC50=140nM
BS02 4BJ B L922 A923 V928 P929 F979 N980 V986 L86 A87 V92 P93 F143 N144 V150 MOAD: ic50=0.14uM
PDBbind-CN: -logKd/Ki=6.85,IC50=0.14uM
BindingDB: EC50=3900nM,IC50=140nM
BS03 ZN B C829 C832 H849 C852 C5 C8 H25 C28
BS04 ZN B C841 C844 C867 C870 C17 C20 C43 C46
External links
PDB RCSB:4ybm, PDBe:4ybm, PDBj:4ybm
PDBsum4ybm
PubMed26061247
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

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