Structure of PDB 4ybj Chain B

Receptor sequence
>4ybjB (length=253) Species: 9031 (Gallus gallus) [Search protein sequence]
AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTMSPEAFLQEAQV
MKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQL
VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGFPIKWTA
PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR
MPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPG
ENL
3D structure
PDB4ybj Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.
ChainB
Resolution2.61 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D123 R125 A127 N128 D141 F144
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4A9 B L273 A293 K295 M314 L322 I336 T338 Y340 M341 S342 K343 G344 H384 L393 V402 A403 D404 F405 L15 A35 K37 M51 L59 I73 T75 Y77 M78 S79 K80 G81 H121 L130 V139 A140 D141 F142
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ybj, PDBe:4ybj, PDBj:4ybj
PDBsum4ybj
PubMed26895387
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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