Structure of PDB 4y9j Chain B

Receptor sequence

>4y9jB (length=593) Species: 6239 (Caenorhabditis elegans)

TITARHTQYSHAKTGGFSQTGPTLHNPYKDDPILDRTLRRLLPESEYMRV
AADLSKFGDRITSEVEHLGRQAELEQPRLEHQDAWGKRVDKLIVCNEWHK
LKQICAEEGVISIGYEDSVDPFVRRIHQVAKLFLFSPSAGLVSCPMAMTD
GAVKTLTSLNLYGKHKLATEAVDRLRSRDPSKAWTSGQWMTEKKGGSDVA
GGCDTYAVQIDKDTYRLHGYKWFSSAVDADVALTLARIVDSDGNALEGSR
GLSLFLLKIRDESGNLNGIQMVRLKNKLGTKQLPTAELLLDGAIAERIGD
QGRGVAGISNMLNITRIHNAVASLGYMRRIISLARDYSTKRVVFGQTQSK
WPLHTTTLAKMEVDTRGSMLLLFEAARLLGLSEAGKSSDVEAMMLRLITP
VLKLYAGKQAVPMVSEGIECFGGQGYMEDTGLPTLLRDAQVTPIWEGTTN
VLSLDVLRVFSGKENILLAFGKRVEQLLGNTKTEDEKLKKSKEAVESALK
QLQKLLVKASDSAIQGETRIDSVARHIAFTIARIYSGALLIDHASDSSVA
NQSDIEVAYRYCCEQPLIDLRWEWFASERVKADREIVFDNFTA

3D structure

• PDB: 4y9j Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids
• Chain: B
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): M208 T209 T333 E464 R476
• Catalytic site (residue number reindexed from 1): M190 T191 T315 E446 R458
• Enzyme Commision number: 1.3.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	R359 V361 F362 Q366 E437 C438 G440 G441 Y444	R341 V343 F344 Q348 E419 C420 G422 G423 Y426
BS02	FAD	B	Q206 M208 T209 G214 S215 F241 S242 S243 W463 T466 V469 L472	Q188 M190 T191 G196 S197 F223 S224 S225 W445 T448 V451 L454
BS03	UCC	B	S161 A165 Q206 S215 S267 R321 V323 S327 L330 N331 R334 A340 R414 W463 E464 V469 R476	S143 A147 Q188 S197 S249 R303 V305 S309 L312 N313 R316 A322 R396 W445 E446 V451 R458

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003995 acyl-CoA dehydrogenase activity
• GO:0005504 fatty acid binding
• GO:0016491 oxidoreductase activity
• GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors

Biological Process

• GO:0006631 fatty acid metabolic process
• GO:1990845 adaptive thermogenesis

External links

• PDB: RCSB:4y9j, PDBe:4y9j, PDBj:4y9j
• PDBsum: 4y9j
• PubMed: 25981666
• UniProt: Q9XWZ2|ACD11_CAEEL Acyl-CoA dehydrogenase family member 11 (Gene Name=acdh-11)