Structure of PDB 4y94 Chain B

Receptor sequence
>4y94B (length=149) Species: 9913 (Bos taurus) [Search protein sequence]
GMATVILESIFLKRNFKKRLFLLTVQKLSYYEYDFERGRRGSKKGSIDVE
KITCVETVVPEKNPPPERQIEQISIIERFPYPFQVVYDEGPLYVFSPTEE
LRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQIL
3D structure
PDB4y94 Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP B K12 N24 K26 R28 Y39 K53 K13 N15 K17 R19 Y30 K44 MOAD: Kd=238nM
BS02 ZN B H143 C154 C155 C165 H124 C135 C136 C146
BS03 IHP B Y40 K52 Y31 K43 MOAD: Kd=238nM
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:4y94, PDBe:4y94, PDBj:4y94
PDBsum4y94
PubMed25699547
UniProtQ3ZC95

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