Structure of PDB 4y85 Chain B

Receptor sequence
>4y85B (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
LSSVRYGTVEDLLAFANHISNPQESGILLNMVITPQNGRYQIDSDVLLIP
WKLTYRNIFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQAC
FRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVT
KHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFP
KDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRS
AYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLK
HEALNP
3D structure
PDB4y85 The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.
ChainB
Resolution2.33 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D253 K255 N258 D270 T290
Catalytic site (residue number reindexed from 1) D169 K171 N174 D186 T206
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 499 B W132 F143 P145 V152 A165 K167 E208 G210 G213 S214 E217 V260 V269 D270 W51 F59 P61 V68 A81 K83 E124 G126 G129 S130 E133 V176 V185 D186 MOAD: ic50=13nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4y85, PDBe:4y85, PDBj:4y85
PDBsum4y85
PubMed25918157
UniProtP41279|M3K8_HUMAN Mitogen-activated protein kinase kinase kinase 8 (Gene Name=MAP3K8)

[Back to BioLiP]