Structure of PDB 4y83 Chain B

Receptor sequence
>4y83B (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
LSSVRYGTVEDLLAFANHISPQESGILLNMVITPQNGRYQIDSDVLLIPW
KLTYRNIGSDFIPRFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQAC
FRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVT
KHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFP
KDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPPS
YLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEAL
NP
3D structure
PDB4y83 The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.
ChainB
Resolution2.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D253 K255 N258 D270 T290
Catalytic site (residue number reindexed from 1) D169 K171 N174 D186 T206
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 49B B W132 I144 R146 A165 K167 M207 G210 G213 S214 E217 V260 V269 W50 I62 R64 A81 K83 M123 G126 G129 S130 E133 V176 V185
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4y83, PDBe:4y83, PDBj:4y83
PDBsum4y83
PubMed25918157
UniProtP41279|M3K8_HUMAN Mitogen-activated protein kinase kinase kinase 8 (Gene Name=MAP3K8)

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