Structure of PDB 4y5w Chain B

Receptor sequence
>4y5wB (length=477) Species: 9606 (Homo sapiens) [Search protein sequence]
KFKTGLRRLQHRVGEIHLLREALQKALAMLLQETTGELEAAKALVLKRIQ
IWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGTRASLT
GRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKP
PLVRADMVTEKQARETGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRC
ERKGTESVTEEKCAVLFSASFTLGPPIQLQALSLPLVVIVHGNQDNNAKA
TILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHF
LFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDL
TKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIA
HVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEA
FRSHYKPEQMGKDGRGYVPATIKMTVE
3D structure
PDB4y5w Structural basis for DNA recognition by STAT6
ChainB
Resolution3.104 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K374 H415 K203 H241 PDBbind-CN: Kd=79nM
BS02 dna B R370 V379 V414 R199 V208 V240 PDBbind-CN: Kd=79nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4y5w, PDBe:4y5w, PDBj:4y5w
PDBsum4y5w
PubMed27803324
UniProtP42226|STAT6_HUMAN Signal transducer and activator of transcription 6 (Gene Name=STAT6)

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