Structure of PDB 4xxb Chain B

Receptor sequence
>4xxbB (length=42) Species: 9606 (Homo sapiens) [Search protein sequence]
EDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDK
3D structure
PDB4xxb Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C305 C308 C319 C322 C13 C16 C27 C30
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4xxb, PDBe:4xxb, PDBj:4xxb
PDBsum4xxb
PubMed26220995
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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