Structure of PDB 4xv2 Chain B

Receptor sequence
>4xv2B (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA
FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASEFE
MKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGGSI
LWMAPEVIRNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGR
GSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARE
3D structure
PDB4xv2 RAF inhibitors that evade paradoxical MAPK pathway activation.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D127 K129 N131 N132 D145 S149
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P06 B S465 V471 A481 K483 L505 L514 F516 T529 W531 C532 F583 G593 D594 F595 S18 V24 A34 K36 L58 L67 F69 T82 W84 C85 F134 G144 D145 F146 MOAD: ic50=0.00539uM
PDBbind-CN: -logKd/Ki=8.27,IC50=0.0054uM
BindingDB: IC50=1.000000nM,EC50=529nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4xv2, PDBe:4xv2, PDBj:4xv2
PDBsum4xv2
PubMed26466569
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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