Structure of PDB 4xu2 Chain B

Receptor sequence
>4xu2B (length=258) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
RDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADI
DGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLSL
AAGLAVLDSVAPLIETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLN
VTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQL
AADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVS
AGDVVHLR
3D structure
PDB4xu2 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
ChainB
Resolution1.85003 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R69 K138 R266
Catalytic site (residue number reindexed from 1) R66 K130 R258
Enzyme Commision number 6.3.4.15: biotin--[biotin carboxyl-carrier protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 44Q B S38 T39 N40 Q63 G66 R67 G68 R69 R72 G73 W74 A75 N130 K138 I142 V155 G156 N158 V166 D167 A170 S35 T36 N37 Q60 G63 R64 G65 R66 R69 G70 W71 A72 N122 K130 I134 V147 G148 N150 V158 D159 A162 MOAD: Kd=0.592nM
Gene Ontology
Molecular Function
GO:0004077 biotin--[biotin carboxyl-carrier protein] ligase activity
GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0008284 positive regulation of cell population proliferation
GO:0036211 protein modification process
Cellular Component
GO:0005737 cytoplasm
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4xu2, PDBe:4xu2, PDBj:4xu2
PDBsum4xu2
PubMed26299766
UniProtI6YFP0|BIRA_MYCTU Biotin--[acetyl-CoA-carboxylase] ligase (Gene Name=birA)

[Back to BioLiP]