Structure of PDB 4xu0 Chain B

Receptor sequence
>4xu0B (length=262) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
DRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGAD
IDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLS
LAAGLAVLDSVAPLIAVPETGLKWPNDVLARGGKLAGILAEVAQPFVVLG
VGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNA
NPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRT
VVVSAGDVVHLR
3D structure
PDB4xu0 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
ChainB
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R69 K138 R266
Catalytic site (residue number reindexed from 1) R67 K134 R262
Enzyme Commision number 6.3.4.15: biotin--[biotin carboxyl-carrier protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 44N B S38 T39 N40 Q63 G66 R67 R69 R72 G73 W74 A75 I83 N130 K138 G141 I142 V155 G156 N158 V166 D167 A170 S36 T37 N38 Q61 G64 R65 R67 R70 G71 W72 A73 I81 N126 K134 G137 I138 V151 G152 N154 V162 D163 A166 MOAD: Kd=0.769nM
Gene Ontology
Molecular Function
GO:0004077 biotin--[biotin carboxyl-carrier protein] ligase activity
GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0008284 positive regulation of cell population proliferation
GO:0036211 protein modification process
Cellular Component
GO:0005737 cytoplasm
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4xu0, PDBe:4xu0, PDBj:4xu0
PDBsum4xu0
PubMed26299766
UniProtI6YFP0|BIRA_MYCTU Biotin--[acetyl-CoA-carboxylase] ligase (Gene Name=birA)

[Back to BioLiP]