Structure of PDB 4xta Chain B

Receptor sequence
>4xtaB (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTKSPFVIYDMNSLMVAI
RIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTM
LASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALEL
DDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESS
QLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDHPLLQEIYKD
3D structure
PDB4xta Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DIF B I281 R288 L330 I341 S342 M364 I52 R59 L101 I112 S113 M135 MOAD: ic50=3.7uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xta, PDBe:4xta, PDBj:4xta
PDBsum4xta
PubMed26445566
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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