Structure of PDB 4xrh Chain B

Receptor sequence
>4xrhB (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
SESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLK
HYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDV
DVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCR
LPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLS
EHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
3D structure
PDB4xrh Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D99 D101 D162
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B W342 G343 G345 K347 T348 D427 D429 Y505 F506 T507 G508 A510 N513 W14 G15 G17 K19 T20 D99 D101 Y177 F178 T179 G180 A182 N185
BS02 dna B T370 Q372 Q464 R514 R517 A518 L527 E529 T42 Q44 Q136 R186 R189 A190 L199 E201
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4xrh, PDBe:4xrh, PDBj:4xrh
PDBsum4xrh
PubMed26836966
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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