Structure of PDB 4xq8 Chain B

Receptor sequence
>4xq8B (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
SESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLK
HYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDV
DVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCR
LPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLS
EHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
3D structure
PDB4xq8 Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
ChainB
Resolution2.798 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D99 D101 D162
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B W342 G343 G345 K347 T348 D427 D429 R488 Y505 T507 G508 A510 N513 W14 G15 G17 K19 T20 D99 D101 R160 Y177 T179 G180 A182 N185
BS02 dna B Q372 V462 E466 N467 R514 R517 A518 K521 L527 S528 E529 Q44 V134 E138 N139 R186 R189 A190 K193 L199 S200 E201
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4xq8, PDBe:4xq8, PDBj:4xq8
PDBsum4xq8
PubMed26836966
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

[Back to BioLiP]