Structure of PDB 4xli Chain B

Receptor sequence
>4xliB (length=264) Species: 10090 (Mus musculus) [Search protein sequence]
DKWEMERTDITMKHKLGGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE
AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVT
AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR
LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG
MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF
AETHQAFETMFHDS
3D structure
PDB4xli Structure of the ABL2/ARG kinase in complex with dasatinib.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D409 A411 R413 N414 D427 P448
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145 P166
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B E398 H536 E116 H254
BS02 1N1 B L294 A315 K317 E332 M336 V345 I359 T361 Y363 M364 P365 G367 L416 A426 L16 A33 K35 E50 M54 V63 I77 T79 Y81 M82 P83 G85 L134 A144 MOAD: Kd=0.17nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xli, PDBe:4xli, PDBj:4xli
PDBsum4xli
PubMed25849507
UniProtQ4JIM5|ABL2_MOUSE Tyrosine-protein kinase ABL2 (Gene Name=Abl2)

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